TNF and periodontitis: Periodontitis is a chronic inflammatory disease of infectious origin and associated with the accumulation of dental microbial biofilm, generally caused by the progression of untreated gingival inflammation, which affects the supporting structures of the tooth and is manifested by the progressive destruction of the periodontal ligament and alveolar bone due to proinflammatory cytokines inducing bone resorption, such as Interleukin 1 beta (IL-1β) and tumor necrosis factor (TNF-α) [1].