Taking into account the slightly higher immunostaining score of NK-1R in comparison with that of CRLR in colorectal adenocarcinomas, we can say that both substance P and NK-1R correlate more than CGRP and CRLR with the tumoral and clinical-pathological characteristics of patients with colorectal cancer but without significant differences. This evidence concerns the gene TACR1 and colorectal adenocarcinoma.