In the PREDICT study, 1071 patients with AD were included; three groups of patients were identified, with a differential white blood cell count and CRP levels (as markers of inflammation); patients with pre-ACLF (n = 218) and who developed ACLF during the first hospitalization (20%) had a mortality rate of 53.7% at 3 months and 67.4% at 1 year. The gene discussed is CRP; the disease is Alzheimer disease.