Additionally, it has been shown that the cytoplasmic interaction of the C-terminal domain of p27 with the protein stathmin, which destabilizes microtubules, interferes with microtubule dynamics and regulates cell migration; instead, the nuclear localization of p27 is necessary for its tumor-suppressive function in mice, and has been linked to the control of cell cycle progression through binding to cyclin/CDK complexes. This evidence concerns the gene CDKN1B and neoplasm.