In a multivariate logistic regression analysis for severe AKI (AKI stages 2–3), high DFR was independently associated with severe AKI, as well as hepatopulmonary syndrome, hepatocellular carcinoma, preoperative albumin, cryoprecipitate transfusion, BMI, oliguria, preoperative creatinine, the intraoperative mean albumin level, and intraoperative hematocrit (AUC: 0.810, CI: 0.778–0.840; sensitivity: 81.48%; specificity: 64.97%; p < 0.001). The gene discussed is ALB; the disease is hepatopulmonary syndrome.