Regarding the CD4+ and CD8+ T-cell phenotypes, we observed that HCMV-specific CD4+ and CD8+ T cells with a terminally differentiated effector memory phenotype (CD45RA+) remained constant in pregnant women with primary infection at the early and late time points and in subjects with remote infection, whereas HCMV-specific CD4+ and CD8+ T cells expressing IL-7R+ or producing IL-2 were higher in control subjects with remote infection than in pregnant women with HCMV primary infection. Here, CD4 is linked to infection.