In this study, we investigated the antigen-specific T-cell response against the non-structural protein IE-1 (produced in the immediate-early phase), the structural protein pp65 (internal tegument protein) and the envelope glycoprotein complexes, including the pentamer gHgLpUL128L and gB, in pregnant women at 2 and 12 months after HCMV primary infection and in control subjects with remote infection. The gene discussed is PROS1; the disease is infection.