If autoantibodies are directed against intracellular antigens, for example Hu proteins, anti-collapsin response mediator protein 5 (CV2/CRMP5), protein Ma2, or glutamic acid decarboxylase 65-kilodalton isoform (GAD65), a T-cell-mediated immune response can be observed with the destruction of the cells and a significantly higher risk of epilepsy [22]. Here, DPYSL5 is linked to epilepsy.