ELN and aging: Skin aging is associated with reduced production of fibroblasts and increased expression of matrix metalloproteinases, which leads to increased degradation of collagen and elastin fibers (as the primary network supporting the skin’s structure and smooth appearance) and the consequent physiological changes at the dermis level are manifested by visible signs such as dryness, laxity, and wrinkles in the face [12,17,51].