Whether a multi-layered risk calculator (a stratified decision) should include other elements such as genetic background (RET or BRAF pathogenic variants), metabolic interplay (e.g., the presence of obesity or diabetes mellitus), or the co-diagnosis of autoimmune conditions (such as autoimmune thyroid disease) or other coagulation anomalies represents a complex matter and an ongoing process [111,112,113,114,115,116]. Here, RET is linked to autoimmune thyroid disease.