Whether a multi-layered risk calculator (a stratified decision) should include other elements such as genetic background (RET or BRAF pathogenic variants), metabolic interplay (e.g., the presence of obesity or diabetes mellitus), or the co-diagnosis of autoimmune conditions (such as autoimmune thyroid disease) or other coagulation anomalies represents a complex matter and an ongoing process [111,112,113,114,115,116]. The gene discussed is RET; the disease is obesity due to melanocortin 4 receptor deficiency.