The extent of thyroidectomy that should be performed in low-risk differentiated thyroid carcinoma is still a subject of debate, as total thyroidectomy might be considered overtreatment, while partial/sub-total thyroidectomy comes with challenges regarding post-surgical follow-up in terms of serum thyroglobulin assay applicability if a large thyroid remnant is already present [85,86,87]. The gene discussed is TG; the disease is differentiated thyroid carcinoma.