The emerging trend is that desmoplakin mutations may underlie diseases that are currently classified heterogeneously but are actually the same condition, presenting with a clinical spectrum that may range from myocarditis as an initiating manifestation in some subjects, to ventricular arrhythmias in others without clinical signs of myocarditis, but with an underlying inflammatory component, possibly due to cellular disruption\apoptosis and subsequent inflammatory activation. The gene discussed is DSP; the disease is myocarditis.