The importance of investigating the genetic substrates of patients affected by myocarditis has been underlined by multiple authors, such as a recent retrospective multicenter study by Ammirati et al. [11], in which it was observed that individuals carrying a pathogenic mutation (89% DSP variant carriers) were more susceptible to recurrent myocarditis and ventricular arrhythmias than genotype-negative patients or individual not subjected to genetic testing (62.3% vs. 17.5% vs. 5.3% at 5 years, p < 0.0001). This evidence concerns the gene DSP and myocarditis.