Cardiac disease phenotypes presenting as myocarditis or as a cardiomyopathy associated with an inflammatory burden bearing mutations of desmosomal proteins, including desmoplakin, are currently heterogeneously classified as inflammatory cardiomyopathies, as ACM, or as relapsing myocarditis with unfavorable evolution (fatal arrhythmias or heart failure). Here, DSP is linked to cardiomyopathy.