Interestingly, HCCs upregulate the expression of menin–MLL complex members such as WDR5, RBBP5, ASH2L, and MLL, in addition to menin [211], suggesting that menin promotes HCC pathogenesis by increasing the activity of the menin–MLL complex and subsequently increasing YAP1 activity. The gene discussed is MEN1; the disease is hepatocellular carcinoma.