Menin expression was also found to be correlated with the expression of the H3K79 histone methyltransferase DOT1L in human ovarian cancers [301], similar to MLL-rearranged leukemia and endocrine-resistant breast cancer cells, where menin regulates DOT1L activity in a pro-tumorigenic manner [198,302]. The gene discussed is DOT1L; the disease is leukemia.