Interestingly, the increase in TERT was due to increased ubiquitylation and subsequent proteasomal degradation of menin by the cullin–RING ubiquitin ligase 4 (CRL4) complex [259], which is upregulated in pro-inflammatory microenvironments, such as those that may occur in the context of CRC [260]. Here, MEN1 is linked to colorectal carcinoma.