Menin expression was also found to be correlated with the expression of the H3K79 histone methyltransferase DOT1L in human ovarian cancers [301], similar to MLL-rearranged leukemia and endocrine-resistant breast cancer cells, where menin regulates DOT1L activity in a pro-tumorigenic manner [198,302]. Here, DOT1L is linked to breast carcinoma.