DOT1L and breast cancer: Menin, DOT1L, and BAZ1B are overexpressed in ductal breast tumors compared to non-malignant mammary tissue [275], and they colocalize to both distal and proximal enhancer-like sites for multiple genes involved in pathways known to play a role in breast cancer, such as estrogen signaling, p53 signaling, HIF1α signaling, death receptor signaling, PI3K/Akt/mTOR signaling, Myc signaling, cell cycle regulation, and EMT [275].