NPM1 and acute myeloid leukemia: Venetoclax synergizes with SNDX-5613, VTP50469 (a closely related analog of SNDX-5613, sometimes referred to as SNDX-50469), KO-539, and MI-503 in MLLr and NPM1 mutant AML cells, with the combinations more significantly reducing cell viability than any of the three MIs alone [189,190,191,192].