Myc expression is associated with increased cell proliferation in AR-positive cell lines [309], and menin promotes Myc expression in AR-positive cells through the methylation of H3K4 at the MYC enhancer [309,310] and by increasing the expression of the lncRNA PCAT1 [309], which has previously been shown to promote prostate cancer pathogenesis through the regulation of Myc expression [311]. Here, MEN1 is linked to Familial prostate cancer.