MEN1 and lung carcinoma: Furthermore, loss of menin in an LSL-KrasG12D/+;Sftpc-Cre mouse model of lung cancer increases the expression of the epithelial marker E-cadherin and reduces the expression of the mesenchymal markers Nestin, Vimentin, and ZEB1 [108], suggesting that menin promotes epithelial-to-mesenchymal transition (EMT) and metastasis of lung tumors.