KMT2A and leukemia: Heikamp and colleagues found that inhibiting the menin–MLL interaction in NUP98 fusion leukemia cell lines with VTP50469 promotes differentiation and inhibits leukemogenesis by evicting MLL and NUP98 fusion proteins from the chromatin at key pro-leukemic gene loci [207], suggesting that the menin–MLL interaction may also function as a key oncogene in NUP98 fusion leukemias.