Menin may further promote HCC tumorigenesis by exacerbating Wnt activation in HCCs with activating Wnt mutations, as the small molecule menin inhibitor MI-503 was also able to reverse the activated CTNNB1-associated gene expression signature in an HCC cell line with an activating mutation in CTNNB1 [212]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.