SCN1A and epilepsy: Furthermore, in a case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy by Baum et al., rs3812718 appeared to have the strongest association with epilepsy in a population with Han Chinese, Chinese, Indian, and Malay ethnicities, and a subsequent meta-analysis confirmed the association, indicating a protective role for the G allele in epilepsy risk [26].