OTU Deubiquitinase 1 (OTUD1; C−A+ quadrant) has been shown to repress type-I interferon-mediated disease, which includes lupus, in vivo [89] and to have loss-of-function in systemic lupus erythematosus [90], suggesting the promise of treatments that increase the activity of OTUD1 in lupus B cells. The gene discussed is OTUD1; the disease is systemic lupus erythematosus.