Transmembrane Anterior Posterior Transformation 1 (TAPT1, C−A− quadrant), ADP Ribosylation Factor Like GTPase 4A (ARL4A, C−A− quadrant), and Proline-Rich Nuclear Receptor Coactivator 1 (PNRC1, C−A− quadrant) are novel results which, as underlying mechanistic genes shared by lupus and lymphoma, could be leveraged as possible therapeutic targets. This evidence concerns the gene PNRC1 and systemic lupus erythematosus.