Transmembrane Anterior Posterior Transformation 1 (TAPT1, C−A+ quadrant) and Proline-Rich Nuclear Receptor Coactivator 1 (PNRC1, C−A+ quadrant) are novel immune imbalance results with no known mechanisms and with promising potential to change pathogenic properties of lupus and lymphoma B cells, which justifies future experimentation. Here, PNRC1 is linked to systemic lupus erythematosus.