Some studies have also found that lipid metabolism disorders will also affect the Nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP-3), thus activating Caspase-1, converting pro IL-1β into mature IL-1β and thereby causing a strong inflammatory response [37]. This evidence concerns the gene CASP1 and Disorder of lipid metabolism.