Our MR results revealed that Linolenate [α or γ; (18:3n3 or 6)] positively mediates the causal relationship between CD19 on PB/PC and HCC (ME = 0.0389, MP = 19.3%), while negatively mediating the causal relationship between CD14 on Mo MDSC and HCC (ME = −0.0128, MP = 10.4%). Here, CD14 is linked to hepatocellular carcinoma.