Caffeic acid could inhibit glucose-regulated protein 75 attenuating the anti-apoptosis abilities and multi-drug resistance of HCC and contribute to the inhibition of the growth and expansion of hepatocellular carcinoma cells through the regulation of the AKT/CyclinD1/p21/p27 pathways [65,66]. Here, AKT1 is linked to hepatocellular carcinoma.