Additionally, 3-hydroxyhexanoate levels showed significant positive mediation impacts (β = 0.0131, 95% CI [0.0024, 0.0238], p = 0.0166) on CCR2 on CD62L+ plasmacytoid DC and HCC, with a mediation proportion of 9.03%. The gene discussed is CCR2; the disease is hepatocellular carcinoma.