The mediation analysis indicated that Linolenate [α or γ; (18:3n3 or 6)] levels exhibited the highest mediation proportion at 19.3%, mediating CD19 on PB/PC to HCC, and also demonstrated significant positive mediation impacts (β =−0.0128, 95% CI [−0.0247, −0.0009], p = 0.0339) on CD14 on Mo MDSC and HCC, contributing a mediation proportion of 10.4%. This evidence concerns the gene CD19 and hepatocellular carcinoma.