PNPLA3 and obesity due to melanocortin 4 receptor deficiency: While dietary interventions may show less efficacy in individuals with the PNPLA3 rs738409 GG genotype compared to those with the CC or CG genotypes, strict adherence to other lifestyle modifications, such as active exercise and no smoking, is crucial for preventing metabolic complications, including obesity, hypertension, diabetes, and dyslipidemia.