Several causative genes have been associated with AD-RP, including RHO, PRPF31, PRPH2, RP1, IMPDH1, PRPF8, NR2E3, snRNP200, KLHL7, CRX, PRPF3, TOPORS, ADIPOR1, ARL3, CA4, FSCN2, GUCA1B, HK1, IMPG1, KIF3B, NRL, PRPF4, PRPF6, RDH12, ROM1, RP9, SEMA4A, SPP2, and many others [6]. Here, NRL is linked to Alzheimer disease.