LIFR and Stüve-Wiedemann syndrome 1: Due to considerable phenotypic overlap, the differential diagnosis should mainly consider two conditions: cold-induced sweating syndrome type 2 (CISS2, OMIM # 610313), caused by mutations in the CLCF1 gene; and Stüve–Wiedemann syndrome/Schwartz-Jampel type 2 syndrome (SWS/SJS2, OMIM #601559), caused by mutations in the LIFR gene [5,6].