CRLF1 and Moebius syndrome: Additionally, the peculiar chewing pattern seen in CS/CISS1 was not attributable to the presence of cognitive retardation, particular behavioral patterns, or profoundly poor muscle tone, as observed in Prader–Willi syndrome (OMIM #176270) [36], Smith–Magenis syndrome (OMIM #182290) [37], and Moebius syndrome (OMIM #1579009) [38].