CD40LG and dengue disease: The United States (US) Centers for Disease Control and Prevention (CDC) recommends [19] that for the acute (first 7 days after symptom onset) dengue diagnosis two strategies may be adopted: (i) rapid immunochromatographic antigen tests targeting non-structural glycoprotein 1 (NS1) plus detection of IgM through antibody capture enzyme-linked immunosorbent assay (ELISA) and (ii) nucleic acid amplification tests like reverse transcription real-time polymerase chain reaction (RT2-PCR) plus IgM serology [19].