The serum level of adiponectin is altered in pregnancy complicated by different pathologies; it is much lower in pregnancy associated with GDM [25,26], obesity [27,28], and preterm labor [29], and higher in pregnancy complicated by preeclampsia [30], suggesting a role of this adipokine in the pathogenesis of these pathologies. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.