With regard to CV and non-CV outcomes, in a substudy of the United Kingdom Prospective Diabetes Study (UKPDS) on overweight patients, those on metformin experienced, respectively, 42% and 36% fewer diabetes-related and all-cause deaths when compared to diet alone arm, and a lower mortality rate than sulfonylureas or insulin arms with an overall risk reduction for myocardial infarction of 33% after a 10-year follow-up [48,49]. This evidence concerns the gene INS and diabetes mellitus.