The results of logistic regression applied to the codominant genotype model showed a significant difference in the genotypic distribution (TT, CT and CC) of the VDR-Fokl gene polymorphism between PCOS cases with acne and without acne (p = 0.034, p-corrected = 0.044) but no significant association between genotypes and acne in women without PCOS (p = 0.215). This evidence concerns the gene VDR and acne.