Other Ambrosia pollen allergen components not yet included in commercial assays, such as plastocyanins Amb 3 and Amb a 7, polcalcins or calcium-binding proteins Amb a 9 and Amb a 10, and enolase Amb a 12, may also contribute to the molecular IgE sensitization profiles of patients with respiratory allergy to ragweed pollen [106]. This evidence concerns the gene IGHE and allergic respiratory disease.