Prentice et al. (2010, 2013) identified proteins, such as B2M, ORM1, and IGFALS, as potential CVD diagnostic markers for stroke and heart disease and B2M, IGFBP1, THBS1, and CFD as predictors of hyperlipidemia and hypertension [50,51]. The gene discussed is IGFALS; the disease is hypertensive disorder.