CALR and autoimmune disease: During pregnancy, maternal anti-Sjögren’s-syndrome-related antigen A (anti-SSA/Ro), anti-Sjögren’s-syndrome-related antigen B (anti-SSB/La), or anti-U1 ribonucleoprotein (anti-U1-RNP) antinuclear autoantibodies can cross the placenta and cause the newborn an autoimmune disorder called neonatal lupus erythematosus (NLS).