The most common cause of VTE in pregnancy is inherited thrombophilia, which encompasses a range of genetic polymorphisms like the factor V Leiden (FVL) mutation, prothrombin G20210A mutation, and deficiencies of protein C (PC), protein S (PS), and antithrombin (AT), as well as methylenetetrahydrofolate reductase enzyme (MTHFR) 1298 and 677 mutations, and the Plasminogen activator inhibitor-1 (PAI-1) mutation [14,15,16]. The gene discussed is SERPINE1; the disease is Rare hereditary thrombophilia.