IL6 and colorectal cancer: On the other hand, in colorectal cancer patients who did not respond to chemotherapy treatment, CXCL8 (p = 0.018), IL6 (p = 0.01), and IL6R (p ≤ 0.001) mRNA levels were higher, while TFGB1 (p ≤ 0.001) mRNA levels were lower, as observed in Figure 3B. The signature profile analysis of CXCL8, IL6, and IL6R revealed a significantly elevated mRNA expression in non-responder colorectal cancer patients (p = 0.099).