PRSS3 and cancer: An increasing number of studies have reported the abnormal expression of circRNAs in different cancer types, for instance, in OC; it was demonstrated that CircRNA-051239 expression is increased in tissues and EVs isolated from the plasma of OC patients; circRNA acts as ceRNA by sponging miR-509-5p to induce Serine protease 3 (PRSS3) expression.