Again in human colon cancer, Devin and colleagues [68] identified a transient increase in the concentration of serum cytokines (i.e., TNFalpha, IL-6, and IL-8) immediately after high-intensity interval exercise in colorectal cancer survivors, which may be an important mechanism contributing to the observed growth suppression effect in colon cancer cells. This evidence concerns the gene IL6 and malignant colon neoplasm.