Again in human colon cancer, Devin and colleagues [68] identified a transient increase in the concentration of serum cytokines (i.e., TNFalpha, IL-6, and IL-8) immediately after high-intensity interval exercise in colorectal cancer survivors, which may be an important mechanism contributing to the observed growth suppression effect in colon cancer cells. The gene discussed is CXCL8; the disease is malignant colon neoplasm.