The expression levels of Sox2 examined here were found to be consistent, with reported characteristics that indicate a strong reduction in the levels of pluripotency-related proteins, especially for Sox2, in the AD postmortem human brain [37] and mouse neuronal stem cells [38], which is most likely accompanied by impaired hippocampal neurogenesis in the early stages of AD as shown in Tg2576 (transgenic mice) resident and SVZ-derived adult neural stem cells [39]. The gene discussed is SOX2; the disease is Alzheimer disease.