DISC1 and schizophrenia: Moreover, genome-wide association studies have reported various schizophrenia risk loci that have been used to create animal models [178], such as Disrupted-in-Schizophrenia 1 (DISC1) [179], dysbindin-1 [180], neurotrophic factor neuregulin 1 (NRG1) and its receptor, epidermal growth factor receptor 4 (ErbB4) [181].