PTHLH and Hypercalcemia: The hormonal burden is reflected by complex interplays such as the galanin system, exposure to sex hormone therapy, interferences with vitamin D system, etc., while humoral hypercalcaemia of malignancy, although rare, has been reported due to parathyroid hormone-related protein over-production in addition to other elements such a fibroblast growth factor receptor-positive or even procalcitonin-positive tumour.