The different pathways for up-regulated differentially expressed genes include tryptophan metabolism, FoxO signaling pathway, p53 signaling pathway, Mucin type O-glycan biosynthesis, biosynthesis of unsaturated fatty acids, C-type lectin receptor signaling pathway, cocaine addiction, fatty acid degradation, and leukocyte transendothelial migration. This evidence concerns the gene CLEC4D and cocaine dependence.