VCAM1 and obesity due to melanocortin 4 receptor deficiency: In this sense, the consumption of mixed nuts (Brazil nuts and cashews) favored the increase in beneficial bacteria and potentially improved pathways associated with the reduction in body fat, in addition to attenuating the increase in intestinal permeability and inflammation, demonstrated by reduced IL-8, after an 8-week obesity dietary treatment [61]; in addition, Brazil nuts and cashew nuts reduced total body fat and at the same time improved the percentage of lean mass and reduced VCAM-1 concentration, improving endothelial function [47] in addition to decreasing ghrelin [16].