STAT3, along with both JAK1 and JAK2, play a role in the proliferation, viability, invasion, and migration of CRC cells by controlling the expression of various genes, including Bcl-2, p16ink4a, p21waf1/cip1, p27kip1, E-cadherin, VEGF, and MMPs [143]. This evidence concerns the gene CDKN1A and colorectal carcinoma.