In addition, the expression of the MC1R gene, which is associated with paracrine effects from keratinocyte signaling, was significantly lower in the groups treated with 50% and 95% ethanolic extracts of B. alba, with relative expression levels of 0.97 ± 0.18 and 0.90 ± 0.10, respectively, compared to the IBMX- stimulated melanoma cells, which had a relative expression level of 1.42 ± 0.06 (p < 0.05). The gene discussed is MC1R; the disease is melanoma.