TYR and melanoma: In the IBMX-induced melanoma cells, pretreatment with the aqueous, 50%, and 95% ethanolic extracts of B. alba significantly inhibited the expression of tyrosinase, encoded by the TYR gene, to 1.19 ± 0.03, 1.26 ± 0.15, and 1.11 ± 0.03, respectively, which are comparable to the levels observed in the arbutin treatment group (0.92 ± 0.12) (Figure 3b).