Additionally, comparative analyses of peripheral blood cytotoxic T lymphocytes’ production profile and intratumoral immune cell subsets demonstrated that patients with elevated IL-6 levels exhibited reduced interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) secretion and a non-T cell-inflamed immunosuppressive tumor microenvironment, respectively. This evidence concerns the gene IFNG and neoplasm.