Thrombocytopenia (defined as platelets ≤ 150,000/mm3) is the most common and first of the abnormal hematologic indices to occur in patients with cirrhosis, followed by leukopenia (defined as a WBC count ≤ 4000/mm3) and anemia (defined as Hb ≤ 13.5 g/dL for men and 11.5 g/dL for women). The gene discussed is GSTM1; the disease is Decreased total leukocyte count.