Using the multivariate Cox regression analysis, the FIB-4 score (aHR: 1.589; 95% CI: 1.262–2.001; p < 0.001) along with type 2 DM (aHR: 5.688; 95% CI: 2.358–13.720, p < 0.001), the Hb level (aHR: 0.524; 95% CI: 0.369–0.745, p = < 0.001), and the albumin level (aHR: 0.538; 95% CI: 0.296–0.978, p = 0.042) were the significant factors associated with the all-cause mortality of HD patients with chronic viral hepatitis after adjusting for related variables (Table 3). This evidence concerns the gene GSTM1 and animal viral hepatitis.