TNFAIP3 and lymphoma: Therefore, rs2230926 SNP of TNF Alpha Induced Protein 3 (TNFAIP3), which is involved in the cytokine-mediated immune and inflammatory responses through inhibition of NF-kappa B activation as well as TNF-mediated apoptosis, was shown to enhance the risk of pSS-associated lymphoma in French and UK cohorts.