Variants of genes like Protein Tyrosine Phosphatase Receptor Type C (PTPRC), Lymphocyte Cell-Specific Protein-Tyrosine Kinase (LCK), Linker For Activation Of T Cells (LAT), Tec Protein Tyrosine Kinase (TEC), and Nuclear Factor Of Activated T Cells 5 (NFAT5), which are involved in TCR signalling, have been associated with susceptibility to autoimmune diseases. Here, NFAT5 is linked to autoimmune disease.