PRAME and neoplasm: Although the first studies considered PRAME staining positive if it was diffusely present in over 76% of the tumor cells (4+) [1], more recently, Kunc et al. suggested in their meta-analysis that PRAME positivity should be interpreted as both 4+ (>75% of the cells) and 3+ (51–75% of the cells) cases in clinical practice due to better sensitivity with reasonable specificity [32].