We then explored the co-expression modules of the key transformations in the DNB module and the WGCNA module using the soft clustering analysis (R package “Mfuzz”), and finally identified four genes (SCD, NARS2, ALDH1A1, and NFXL1) that may be related to castration resistance development in PCa patients. This evidence concerns the gene NFXL1 and posterior cortical atrophy.