Most of the available molecular data have reported slight genomic differences between primary UTUC and primary genetically unrelated UBC [11,14], indicating that UTUC seems to display more frequent mutations in FGFR3 and HRAS, whereas UBC harbors TP53, RB1, ATM, and ERBB2 mutations [11,12,13,14,28]. The gene discussed is ERBB2; the disease is renal pelvis/ureter urothelial carcinoma.