Baessler et al. showed that in subjects with morbid obesity, GDF-15 levels seem to better correlate with left ventricle diastolic dysfunction than NT-proBNP levels and that the addition of GDF-15 to NT-proBNP and established risk factors improves reclassification for the diagnosis of diastolic disfunction with possible heart failure, and adds incremental value to NT-proBNP [97]. This evidence concerns the gene NPPB and morbid obesity.