As illustrated in the heatmap (Figure 1C), high expression of a total of nine PSMs (PSMA7, PSMB3, PSMB8, PSMB9, PSMC5, PSMD4, PSMD14, PSME2, and PSMG1) were strongly associated with adverse OS in AML, consistently observed in at least three datasets without contradictory statistical significance. This evidence concerns the gene PSMD14 and acute myeloid leukemia.