Conversely, we observed decreased expression of 10 PSMs (PSMA3, PSMB4, PSMB5, PSMB7, PSMD1, PSMD12, PSME1, PSMF1, PSMG1, and PSMG2) when comparing AML to CD34-positive cells, and 5 PSMs (PSMB2, PSMB9, PSMC3IP, PSMD11, and PSMF1) when compared to MNCs. This evidence concerns the gene PSMB4 and acute myeloid leukemia.