As illustrated in the heatmap (Figure 1C), high expression of a total of nine PSMs (PSMA7, PSMB3, PSMB8, PSMB9, PSMC5, PSMD4, PSMD14, PSME2, and PSMG1) were strongly associated with adverse OS in AML, consistently observed in at least three datasets without contradictory statistical significance. The gene discussed is PSMB3; the disease is acute myeloid leukemia.