Our findings revealed that a total of 12 PSMs exhibited higher expression in AML compared to MNCs, specifically PSMA1, PSMA2, PSMA4, PSMA5, PSMA7, PSMB1, PSMD2, PSMD3, PSMD4, PSMD8, PSMD13, and PSMG2. Here, PSMD3 is linked to acute myeloid leukemia.