TLR4 and Hepatic fibrosis: Their study found a positive correlation between serum TLR4 levels and liver fibrosis severity, with levels increasing as the fibrosis stage progressed (area under the curve (AUC) values of 0.862 for mild fibrosis (≥F1), 0.810 for significant fibrosis (≥F2), and 0.905 for advanced fibrosis (≥F3), all statistically significant (p < 0.001).