IL6 and neoplasm: These findings in context of recent papers by Suzuki et al. [26] and Schoetz et al. [27], highlighting the relevance of through-irradiation-induced, pro-inflammatory, and senescence-associated cytokines (like IL-6) and their role in radioresistance of HNSCC, enhance our comprehension of the pathophysiological mechanisms linking smoking and inferior outcomes of smokers when their tumor was irradiated.