Their study showed that a 3-week isolation period after birth in a transgenic mouse model with a dominant-negative DISC1 (disrupted in schizophrenia 1) under the control of the prion protein promoter (DISC1-DN-Tg-PrP) led to severe impairments on the prepulse inhibition test, increased immobility time in the FST, and altered locomotor activity in DISC1-DN-Tg-PrP adolescent mice. Here, DISC1 is linked to schizophrenia.