ADIPOQ and inflammatory bowel disease: However, other studies have also demonstrated that adiponectin increases T-cell activation, which in turn increases inflammation by amplification of the Th17 and T follicular helper (Tfh) cell response in collagen-induced arthritis [326] and by increasing the expression of B-cell lymphoma-extra large (Bcl-xL) and B-cell lymphoma 2 (Bcl-2), anti-apoptotic proteins, in IBD patients [327], enhancing T-cell production and inflammation.