RETN and obesity due to melanocortin 4 receptor deficiency: An example of altered adipokines associated with obesity includes an increase in leptin and resistin levels, along with a decrease in adiponectin levels, which altogether predisposes obese individuals to develop cardiometabolic diseases, nonalcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), and autoimmune diseases [5,9].