Various hypotheses have been proposed and nowadays the most prominent is that its neuronal loss is associated with the formation of α-synuclein (αSyn) aggregates in neurons of the substantia nigra, known as Lewy bodies (LBs) and Lewy neurites, leading to a perception of it being αSyn-associated proteinopathy and implicating αSyn as a central player in the pathogenesis of PD [2]. This evidence concerns the gene SNCG and Parkinson disease.