Furthermore, CD44+ HNSCC has been known to induce the immunosuppressive cells, like regulatory T cell (Treg) and myeloid-derived suppressor cells (MDSC), which have high immunosuppressive cytokines like interleukin-8 (IL-8) and transforming growth factor beta [158,163]. The gene discussed is CXCL8; the disease is head and neck squamous cell carcinoma.